HORDB

ID: hor002124
Uniprot ID: P22969
Protein name: Relaxin A chain
Gene name: RLN
Organism: Equus caballus (Horse)
Family: Insulin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Equus (genus), Equidae (family), Perissodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: QLSHKCCYWGCTRKELARQC
Length: 20(163-182)
Propeptide: MRRLFLSHVLGAWLLLSQLPRELSGQKPDDVIKACGRELARLRIEICGSLSWKKTVLRLEEPGLEAGQPVEIVSSSISKDAEALNTKLGLNSNLPKEQKATLSERQPSWRELLQQPALKDSNLNLEEFEETILKTQSEVEDDSLSELKNLGLDKHSRKKRMIQLSHKCCYWGCTRKELARQC
Signal peptide: MRRLFLSHVLGAWLLLSQLPRELSG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002124_AF2.pdb

hor002124_ESM.pdb

Mass:	275293	Formula:	C101H161N33O28S4
Absent amino acids:	DFIMNPV	Common amino acids:	C
pI:	8.68	Basic residues:	5
Polar residues:	8	Hydrophobic residues:	4
Hydrophobicity:	-76	Boman Index:	-4956
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	44
Instability Index:	3313	Extinction Coefficient cystines:	7240
Absorbance 280nm:	381.05